Disrupted maternal behavior in morphine-dependent pregnant rats and anhedonia in their offspring.

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Tác giả: Iyanuoluwa Adedokun, Anne Z Murphy, Christopher T Searles, Meghan E Vogt

Ngôn ngữ: eng

Ký hiệu phân loại: 978.02 1800–1899

Thông tin xuất bản: England : Neuropharmacology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 468975

It is currently estimated that every 15 minutes an infant is born with opioid use disorder and undergoes intense early life trauma due to opioid withdrawal. Clinical research on the long-term consequences of gestational opioid exposure reports increased rates of social, conduct, and emotional disorders in these children. Here, we investigate the impact of perinatal opioid exposure (POE) on behaviors associated with anhedonia and stress in male and female Sprague Dawley rats. Young adult female rats were administered morphine via programmable, subcutaneous micro-infusion pumps before, during, and through one week post gestation. For the first two postnatal weeks, maternal behavior was examined for fragmentation and unpredictability. Unpredictable behavioral patterns were quantitatively characterized as entropy scores. Offspring were assessed for sucrose preference, social behavior, and stress responsivity. Overall, dams that received morphine across gestation displayed significantly less pup-directed behavior with increased fragmentation for nursing and higher entropy scores. In adolescence, male and female rat offspring exposed to morphine displayed reduced sucrose preference and, as adults, spent significantly less time interacting with familiar conspecifics. Changes in social behaviors were linked to increased activity in nondopaminergic cells of mesolimbic reward brain regions. Although no treatment effects were observed in forced swim test performance, corticosterone levels were significantly increased in POE adult males. Together, these results suggest that perinatal morphine exposure promotes anhedonic behavior, possibly due to fragmented and unpredictable maternal behavior in opioid-dependent dams.
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