To promote the engineering application of polymer-based cement joint sealant (PCJS), the durability of PCJS was studied by testing the bonding, tensile and shear properties of PCJS under different service conditions. The results show that PCJS has excellent water resistance, acid/alkali corrosions resistance, UV aging resistance and low temperature resistance. The retention rate of bonding property of PCJS can achieve 85%. After water soaking, dry-wet cycle, acid/alkali corrosion, the retention rates of tensile and shear properties of PCJS can achieve 80%. After UV aging and low temperature treatment, the tensile and shear properties of PCJS are improved. After gasoline corrosion and high temperature treatment, the retention rates of tensile and shear properties of PCJS exhibit larger than 60%. The durability indexes of PCJS fulfill the technical requirements, and PCJS exhibits even more superior properties. Consequently, PCJS can be applied to joint engineering of cement concrete pavement.