A better mechanical resistance and improved thermal conductivity, as compared to mono nano-liquids, can be attained by the ethylene glycol-based hybrid nanofluids. These fluids have substantial uses in several engineering systems. The main focus, in the recent work, is to assess the dynamics of the ethylene glycol-based hybrid nano-structured fluid via the computational fluid dynamics (CFD) and machine learning (ML) approaches. The nano-composition of single-walled carbon nanotubes (SWCNTs) and titanium dioxide (TiO