Alternatively spliced NFKB1 transcripts enriched in Andean Aymara modulate inflammation, HIF and hemoglobin.

• Tác giả: Ricardo Amaru, Jacob E Crawford, Seonggyun Han, Dongwook Kim, Soo Jin Kim, Lucie Lanikova, Younghee Lee, Josef T Prchal, Teddy Quispe, Jihyun Song
• Ngôn ngữ: eng
• Ký hiệu phân loại: 333.3323 Private ownership of land
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 469309

Tóm tắt

The molecular basis of increased hemoglobin in Andean Aymara highlanders is unknown. We conducted an integrative analysis of whole-genome-sequencing and granulocytes transcriptomics from Aymara and Europeans in Bolivia to explore genetic basis of the Aymara high hemoglobin. Differentially expressed and spliced genes in Aymaras were associated with inflammatory and hypoxia-related pathways. We identified transcripts with 4