Product and trial design considerations on the path towards a vaccine to combat opioid overdose.

• Tác giả: Asimenia Angelidou, Lindsey R Baden, Melissa Brogna, David J Dowling, Aisling Kelly, Jacob A Koster, Pooja Lalwani, Ofer Levy, Sharon Levy, Kerry McEnaney, Caitlyn McLoughlin, Ahsan Saeed, Amy C Sherman, Elissa R Weitzman
• Ngôn ngữ: eng
• Ký hiệu phân loại: 128.6 Body ,
• Thông tin xuất bản: England : NPJ vaccines , 2025
• Bộ sưu tập: NCBI
• ID: 469324

Tóm tắt

Opioid overdose deaths are an evolving public health emergency in the United States. Recent advancements in drug conjugate vaccine design and adjuvantation technologies have re-ignited interest in the potential clinical utility of opioid vaccination. Here we present the concept of fentanyl vaccination as a complementary strategy for opioid overdose prevention with a focus on vaccine safety, efficacy, and considerations for vaccine development and testing in early phase human clinical trials.