OBJECTIVE: The purpose of this systematic review and meta-analysis was to determine the prevalence of COVID-19 vaccine hesitancy among Nigerian healthcare professionals. METHODS: An extensive language-unrestricted literature search was conducted across PubMed, Scopus, the Cochrane Library, and the African Index Medicus to identify studies reporting hesitancy to COVID-19 vaccines among healthcare workers in Nigeria. Quality assessment was performed using the Newcastle-Ottawa scale for cross-sectional studies. A single-arm meta-analysis was performed using a random-effects model. RESULTS: Of the 206 articles, 22 publications with 20,724 participants were included. The pooled prevalence of COVID-19 vaccine hesitancy was 75% (95% CI: 61%-88%, I CONCLUSION: There was significant hesitancy among Nigerian healthcare workers towards COVID-19 vaccination
thus, strategies to increase vaccination acceptance among healthcare workers should be developed.