Retinal microstructure and microvasculature in association with brain amyloid burden.

• Tác giả: Alison G Abraham, Jennifer A Deal, Marco Egle, Rebecca F Gottesman, Ali G Hamedani, Pradeep Y Ramulu, A Richey Sharett, Keenan A Walker, Dean F Wong
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Brain communications , 2025
• Bộ sưu tập: NCBI
• ID: 469824

Tóm tắt

Cortical amyloid burden is associated with neuronal and vascular abnormalities. The retina shares significant structural and physiological similarities with the brain. This study assessed the association of retinal microstructural and microvascular signs with cortical amyloid burden in the prospective Atherosclerosis Risk in Communities-Positron Emission Tomography study. One hundred and twenty-four participants without a diagnosis of dementia underwent florbetapir PET (2011-13) and optical coherence tomography and optical coherence tomography angiography imaging (2017-19). Retinal nerve fibre thickness, total macular thickness and the ganglion cell-inner plexiform layer thickness were derived from the optical coherence tomography scan. Vessel density and the foveal avascular zone were measured on the 3 × 3 mm