Continuous positive airway pressure (CPAP) therapy is commonly prescribed for obstructive sleep apnea. However, improper cleaning and maintenance of CPAP equipment can create an environment that encourages bacterial colonization, leading to opportunistic respiratory infections in patients, especially in immunocompromised patients with concomitant comorbidities such as chronic obstructive pulmonary disease (COPD). We describe the case of a 57-year-old male patient with a history of chronic bronchitis, bronchiectasis, COPD, and obstructive sleep apnea who presented to the emergency department with worsening dyspnea, productive cough, and respiratory distress. Imaging revealed pneumonia and a respiratory pathogen panel identified