Background Clear communication is vital in anesthesiology to ensure patient safety and deliver high-quality care. Communication errors remain a significant cause of medical errors worldwide. The Modified Kalamazoo Consensus Statement Checklist (MKCSC) offers a structured approach to assessing communication skills. This study evaluates the reliability, validity, and applicability of the MKCSC in India's diverse, multidisciplinary healthcare setting, focusing on its impact on improving communication and patient care through the Program for the Approach to Complex Encounters (PACE). Aim This study aimed to assess the effectiveness of the MKCSC in evaluating and enhancing communication skills among physicians, resident doctors, and nurses and to examine the role of PACE in improving communication outcomes. Methods A repeated cross-sectional study was conducted at Dr. Rela Institute and Medical Center, Chennai, involving 200 participants, including doctors (≥2 years post-MD), resident doctors, and nurses. Participants underwent pre-intervention simulations assessed using the MKCSC, followed by PACE training. Communication scores were evaluated at one-month and five-month follow-ups using paired t-tests, intra-class correlation coefficients (ICCs) for interrater reliability, and Cronbach's alpha for internal consistency. Results The MKCSC demonstrated excellent internal consistency (Cronbach's alpha: 0.89-0.91) and interrater reliability (ICC: 0.85-0.88). Communication scores improved significantly from 23.5 ± 1.4 pre-intervention to 28.9 ± 2.1 at one month and 30.5 ± 2.2 at five months (p <
0.001). Improvements were consistent across professional groups, with significant gains in building relationships and understanding perspectives. Conclusion The MKCSC is a reliable and adaptable tool for assessing communication skills. Combined with PACE, it fosters empathy, enhances teamwork, and bridges communication gaps, contributing to improved patient safety. Further research is needed to validate its use in real-world clinical settings and expand its impact on healthcare delivery.