Induction of enhanced stem-directed neutralizing antibodies by HA2-16 ferritin nanoparticles with H3 influenza virus boost.

• Tác giả: Yaotian Chang, Xianbin Cheng, Xinyu Liang, Qicheng Liu, Xiaoxi Liu, Zejinxuan Liu, Jiaojiao Nie, Yaming Shan, Yuhua Shi, Weiheng Su, Lulu Sun, Qingyu Wang, Yingwu Wang, Yangang Wei, Xin Yao, Xinran Zhang, Yong Zhang, Qi Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 025.317 *Conversion and maintenance
• Thông tin xuất bản: England : Nanoscale advances , 2025
• Bộ sưu tập: NCBI
• ID: 470034

Tóm tắt

Current seasonal influenza vaccines offer limited protection against influenza viruses due to genetic drift. The urgent need for a universal influenza vaccine to combat highly mutated strains is evident. This study utilized the conserved HA2 subunit of hemagglutinin (HA) and a short linear epitope of HA2 (HA2-16) from the H3 influenza virus to conjugate with ferritin, resulting in the construction of recombinant immunogens termed HA2-F and HA2-16-F, respectively.