WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Childhood trauma represents a critical risk factor for substance use among young populations globally, presenting a substantial public health challenge. WHAT IS ADDED BY THIS REPORT?: This comprehensive investigation elucidates the distinct associations between specific subtypes of childhood trauma and substance use behaviors within the Chinese youth population. The findings demonstrate significantly elevated risks for smoking, e-cigarette use, and alcohol consumption, particularly among individuals who have experienced severe or multiple forms of childhood trauma. WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: Implementation of targeted interventions and support systems is essential for individuals with childhood trauma histories. Healthcare providers should emphasize early identification and trauma-informed care approaches. Policy frameworks promoting early intervention and sustained support mechanisms are crucial for reducing substance use behaviors and enhancing population health outcomes.