BACKGROUND: Vulvar cancer is a relatively rare malignant tumor that receives less attention than other gynecological malignancies. Short-video apps are playing an important role in promoting health. This study evaluated the quality of videos about vulvar cancer on YouTube with the aim of making facts-based recommendations and promoting public health engagement. METHODS: On May 15, 2024, the term "vulvar cancer" was searched on YouTube, and the top 100 videos identified in the search were chosen for our research. We evaluated the completeness of each video using six dimensions. The video quality was evaluated using the DISCERN instrument (Quality Criteria for Consumer Health Information), the RESULTS: Among the 65 videos that were included in this study, the majority (64.6%) were posted by educational and training institutes. The quality of the videos submitted by physicians was comparatively good, as indicated by the GQS scores (P=0.045). The relationships between the DISCERN categorization score and duration (P<
0.001), views per day (P=0.02), likes per day (P<
0.001), comments per day (P=0.03), PEMAT actionability (P<
0.001), and GQS scores (P<
0.001) were statistically significant. Additionally, there was a strong positive correlation between the GQS score and video length. CONCLUSIONS: The quality of videos about vulvar cancer on YouTube is unsatisfactory. However, several measures can be adopted in the future to make YouTube a more practical tool for promoting the prevention and cure of vulvar cancer.