Peritoneal carcinomatosis (PC) is typically treated by cytoreductive surgery (CRS) and subsequent chemotherapy. Sealing hemostatic patches (HP) are often used during these surgeries to prevent complications such as uncontrolled bleeding. These HP are made of biomaterials like oxidized cellulose or collagen with a binding agent, and beyond their usual function, they could also be used as drug delivery systems (DDS) for localized intraperitoneal chemotherapy in the tissue attached. Our first aim was to characterize and compare three different commercial HP (TachoSil®, Hemopatch®, and Veriset