Toward the Treatment of Glioblastoma Tumors Using Photoactivated Chemotherapy: In Vitro Evaluation of Efficacy and Safety.

• Tác giả: Sylvestre Bonnet, Anja Busemann, Sina Katharina Goetzfried, Matthijs L A Hakkennes
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.9325 Spiritualism
• Thông tin xuất bản: United States : ACS pharmacology & translational science , 2025
• Bộ sưu tập: NCBI
• ID: 470589

Tóm tắt

Glioblastoma multiforme (GBM) is highly aggressive, necessitating new therapies. Photoactivated chemotherapy (PACT) offers a promising approach by activating prodrugs with visible light at the tumor site. This study evaluated the anticancer activity of ruthenium-based PACT compounds in U-87MG glioblastoma cells and their safety in SH-SY5Y neuron-like cells. The compound [