Spirotetrahydroisoquinoline-Based Histone Deacetylase Inhibitors as New Antifibrotic Agents: Biological Evaluation in Human Fibroblasts from Bronchoalveolar Lavages of Idiopathic Pulmonary Fibrosis Patients.

• Tác giả: Lucia Altucci, Elena Bargagli, Rosaria Benedetti, Laura Bergantini, Stefania Butini, Paolo Cameli, Giuseppe Campiani, Sabrina Carbone, Gabriele Carullo, Chiara Contri, Miriana D'Alessandro, Anna Fontana, Sara Gangi, Sandra Gemma, Alessio Lodola, Marco Mor, Chiara Papulino, Silvia Pasquini, Alex Pezzotta, Anna Pistocchi, Simona Saponara, Laura Scalvini, Katia Varani, Fabrizio Vincenzi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 623.4594 Ordnance
• Thông tin xuất bản: United States : ACS pharmacology & translational science , 2025
• Bộ sưu tập: NCBI
• ID: 470598

Tóm tắt

Idiopathic pulmonary fibrosis (IPF) is a rare interstitial lung disease typified by a progressive fibrosing phenotype. IPF has been associated with aberrant HDAC activity, particularly HDAC6. Combining synthetic and modeling studies, a new family of spirotetrahydroisoquinoline-capped histone deacetylase inhibitors