Transplantation of engineered endothelial progenitor cells with H19 overexpression promotes arterial reendothelialization and inhibits neointimal hyperplasia.

• Tác giả: Tang Deng, Lin Huang, Yunyan Liu, Yunhao Sun, Kangjie Wang, Rui Wang, Ridong Wu, Chen Yao, Yanchen Ye, Zhihao Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: England : Journal of tissue engineering , 2025
• Bộ sưu tập: NCBI
• ID: 470650

Tóm tắt

Endothelial injury is a key factor initiating in-stent restenosis (ISR) following peripheral artery stent implantation. Genetically modified endothelial progenitor cells (EPCs) can promote reendothelialization of injured arteries and inhibit neointimal hyperplasia. However, the role of engineered EPCs overexpressing lncRNA H19 in these processes remains unclear. We constructed EPCs overexpressing lncRNA H19 and investigated their effects and mechanisms in promoting reendothelialization and inhibiting neointimal hyperplasia both