Differential expression of the MYC-Notch axis drives divergent responses to the front-line therapy in central and peripheral extensive-stage small-cell lung cancer.

• Tác giả: Luonan Chen, Xiaoxia Chen, Lei Cheng, He Du, Guanghui Gao, Tao Jiang, Wei Li, Xuefei Li, Qian Liu, Libo Luo, Shiqi Mao, Shengxiang Ren, Jingyun Shi, Yan Wang, Fengying Wu, Rui Xia, Shuo Yang, Jia Yu, Chao Zhao, Caicun Zhou, Fei Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: China : MedComm , 2025
• Bộ sưu tập: NCBI
• ID: 470653

Tóm tắt

Central and peripheral extensive-stage small-cell lung cancer (ES-SCLC) are reported to be two distinct tumor entities, but their responses to the front-line therapies and underlying biological mechanisms remain elusive. In this study, we first compared the outcomes of central and peripheral ES-SCLC receiving front-line chemotherapy or chemo-immunotherapy with a cohort of 265 patients. Then we performed single-cell RNA sequencing (scRNA-seq) on nine treatment-naïve ES-SCLC samples to investigate potential mechanisms underlying the response differences. Under chemotherapy, the peripheral type had a lower objective response rate (44.8% vs. 71.2%,