CONTEXT: Root perforation increases the fracture risk, and bioceramic materials can be used for repair. Evaluating the fracture resistance (FR) of these cements in teeth with simulated perforations is crucial for assessing their effectiveness. AIM: The aim of the study was to evaluate the effect of Biodentine (Septodont, France) and Mineral Trioxide Aggregate High Plasticity (MTA Repair HP, Angelus, Brazil), on the FR of teeth with simulated root perforations. DESIGN AND SETTINGS: An MATERIALS AND METHODS: Fifty extracted mandibular premolars were randomly assigned to one control group ( STATISTICAL ANALYSIS: The variance among the five groups was tested using Analysis of Variance and pairwise RESULTS: The highest mean FR value was observed in the MTA HP + MTA HP group. ANOVA test revealed statistically significant differences between the groups ( CONCLUSION: Bioceramic cements with a MOE similar to dentin enhance FR by forming a monoblock for uniform stress distribution. Perforation repair and backfilling with these cement reinforce the tooth.