Genetic insights into avian influenza resistance in Jeju Island chickens: the roles of Mx1 and oligoadenylate synthetase-like single nucleotide polymorphisms.

• Tác giả: Seohyun Jeong, Sung Hyun Kang, Woo Hyun Kim, Young-Won Kim, Eun-A Ko, Jae-Hong Ko, Seong-Hwan Mun, Dongseob Tark, Hyoung-Seok Yang, Ju-Hee Yang
• Ngôn ngữ: eng
• Thông tin xuất bản: Korea (South) : Journal of animal science and technology , 2025
• Bộ sưu tập: NCBI
• ID: 470869

Tóm tắt

Influenza A virus (FLUAV) causes serious diseases in both poultry and humans. Various host proteins, including Mx1, are considered candidates for avian influenza (AI) resistance. After infecting Jeju Native chicken embryo fibroblasts (CEFs) with three types of AI viruses, we performed gene expression profiling, identified single nucleotide polymorphisms (SNPs) through RNA-sequencing, and confirmed phenotypes showing antiviral activity