Sick sinus syndrome and high-degree atrioventricular block in dementia with Lewy bodies and other dementia subtypes: A study of ≈ 73,000 patients with dementia.

• Tác giả: Maria Eriksdotter, Mattias Haglund, Isak Heyman, Elisabet Londos
• Ngôn ngữ: eng
• Ký hiệu phân loại: 516.353 Algebraic varieties of higher dimensions
• Thông tin xuất bản: United States : Alzheimer's & dementia (New York, N. Y.) , 2025
• Bộ sưu tập: NCBI
• ID: 471092

Tóm tắt

 INTRODUCTION: Lewy body pathology is commonly found in cardiac nervous tissue, including the cardiac conduction system. This study aimed to investigate the occurrence of sick sinus syndrome (SSS) and high-degree atrioventricular block in dementia with Lewy bodies (DLB) compared to Alzheimer's disease (AD) and other dementia subtypes. METHODS: We included 73,619 individuals diagnosed with dementia from the Swedish Dementia Registry. Data pertaining to incident pacemaker implantation was obtained from the Swedish Pacemaker Registry. RESULTS: SSS was more common in the DLB compared to the AD cohort (2.2% vs. 1.5%, DISCUSSION: We showed that incident pacemaker implantation secondary to SSS was more common in patients with DLB compared to those with AD. HIGHLIGHTS: Incident pacemaker implantation secondary to sick sinus syndrome (SSS
  but not high-degree atrioventricular block [HAVB]) was more common in dementia with Lewy bodies (DLB) versus Alzheimer's disease (AD).In adjusted models, SSS (but not HAVB) was positively associated with DLB compared to AD.Pacemaker data of various dementia disorders are presented.