BACKGROUND: Platelet-type von Willebrand disease (PT-VWD) is a rare autosomal dominant disorder. It is caused by gain-of-function gene variants in the platelet OBJECTIVES: To establish the worldwide and within distinct ethnic groups prevalence of PT-VWD. METHODS: We used available exome and genome sequencing data of 807,162 (730,947 exomes and 76,215 genomes) subjects from the Genome Aggregation Database (gnomAD-v4.1). RESULTS: Among the 1,614,324 alleles analyzed in the gnomAD population, there were 1397 distinct CONCLUSION: This population-based genetic epidemiology analysis indicates a substantially higher than expected frequency of PT-VWD. This novel finding suggests that a large number of PT-VWD patients are still under- or misdiagnosed.