Climate change is one of the major challenges for humanity in the 21st century, has negatively affected many sectors. This work aimed at assessing impacts of climate change (CC) on agricultural sector in Vinh Long province till 2020 via data collection and processing method, Geographic Information System (GIS), risk assessment matrix, and SWOT. Flood, saltwater intrusion (SI), drought, landslide, storm, temperature, and precipitation were taken into consideration. Flood, SI, and temperature were found as main factors affecting on agricultural sector in Vinh Long province, especially rice. In Vinh Long province, Vung Liem, Long Ho, and Binh Tan districts were significantly effected. Besides, this work proposed some solutions to improve the adaptive capacity to CC of this sector, contributing to the local sustainable development.