Trichinellosis, one of the parasitic zoonoses, is treated with a benzimidazole derivative, primarily albendazole. However, this treatment has a lot of side effects and is not sufficiently effective in killing the encysted larvae. Silymarin, a polyphenolic flavonoid, has been proven to have anti-parasitic activities and various medical uses. The current study aimed to evaluate silymarin efficacy against intestinal and muscular phases of murine trichinellosis compared to the standard drug
albendazole. Forty-eight mice were divided into four discrete groups: healthy model
diseased model
silymarin treatment
and albendazole treatment. The assessment of therapy efficacy was conducted parasitologically through counting the adult worms and muscle larvae, histopathologically through examination of the intestinal and muscular tissues, and, immunohistochemically through muscular expression of the vascular endothelial growth factor. Both silymarin and albendazole-treated groups demonstrated a statistically significant decrease (