An isofagomine analogue with an amidine group in the 1,6-position.

• Tác giả: Finn L Aachmann, Idd Andrea Christensen, Tereza Cristina Santos Evangelista, Emil Lindbäck, Óscar López, Monika Moreń, Ljupcho Pejov, Magne O Sydnes, I Caroline Vaaland Holmgard, Nikolai Westlund
• Ngôn ngữ: eng
• Ký hiệu phân loại: 709.04014 Historical, geographic, persons treatment of fine and decorative arts
• Thông tin xuất bản: England : Royal Society open science , 2025
• Bộ sưu tập: NCBI
• ID: 471654

Tóm tắt

The synthesis of an isofagomine analogue with an amidine group in the 1,6-position is described. Density functional theory calculations showed that this compound has a remarkably different charge distribution compared with isofagomine. This may explain why the amidine is a poor glycosidase inhibitor (IC