BACKGROUND: To compare the risk factors, clinical outcomes, and mortality rates between carbapenem-resistant METHODS: A retrospective cohort study was conducted on patients with RESULTS: The study included 283 patients, with 104 (36.7%) infected by CRKP and 179 (63.3%) by CSKP. CRKP patients had significantly higher body temperature, white blood cell counts, and inflammatory markers, while showing lower diastolic blood pressure and oxygen saturation ( CONCLUSION: Patients with CRKP infections had higher mortality rates and longer hospital stays than those with CSKP infections. Previous hospitalization, hospitalization in an ICU, and mechanical ventilation were independent risk factors for CRKP infection.