BACKGROUND: The rise in environmental pollutants has become a pressing global concern of international magnitude. Substantial evidence now demonstrates that escalating global temperatures and rising sea levels might exacerbate release of chemical pollutants into the environment which amplifies their toxicity. Existing research underscores the linkage between climate change and air pollution as driving forces, with increased mortality and morbidity. PURPOSE OF REVIEW: This review explores the reciprocal relationship between climate change and its impact on health, as well as the environment. We conducted an in-depth analysis of all relevant published studies, encompassing studies conducted across various regions worldwide, including the Eastern Mediterranean Regional Office (EMRO) SUMMARY: The environmental consequences of climate change have widespread impacts on various health systems and populations. Knowledge gaps remain in understanding the full scope of climate change effects, particularly through environmental pollution. The findings of this review highlight the need for global strategies to mitigate diverse health risks to protect from the growing threats of climate change.