Discovery of a selective and reversible LSD1 inhibitor with potent anticancer effects

• Tác giả: Jin-Zhan Liu, Ying-Ying Mei, Li-Wei Sun, Meng Zhang, Xiao-Song Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 615.7822 Pharmacokinetics
• Thông tin xuất bản: England : Journal of enzyme inhibition and medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 472481

Tóm tắt

Lysine-specific demethylase 1 (LSD1) is abnormally overexpressed in various tumour tissues of patients and has been an attractive anticancer target. In this work, a potent LSD1 inhibitor (compound