Poly-epigenetic scores for cardiometabolic risk factors interact with demographic factors and health behaviors in older US Adults.

• Tác giả: Kira S Birditt, Jessica D Faul, Sharon L R Kardia, Zheng Li, Lisha Lin, Colter Mitchell, Scott M Ratliff, Jennifer A Smith, Yi Zhe Wang, Wei Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 343.05242 Military, defense, public property, public finance, tax, commerce (trade), industrial law
• Thông tin xuất bản: United States : Epigenetics , 2025
• Bộ sưu tập: NCBI
• ID: 472529

Tóm tắt

 Poly-epigenetic scores (PEGS) are surrogate measures that help capture individual-level risk. Understanding how the associations between PEGS and cardiometabolic risk factors vary by demographics and health behaviors is crucial for lowering the burden of cardiometabolic diseases. We used results from established epigenome-wide association studies to construct trait-specific PEGS from whole blood DNA methylation for systolic and diastolic blood pressure (SBP, DBP), body mass index (BMI), C-reactive protein (CRP), high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglycerides (TG), and fasting glucose. Overall and race-stratified associations between PEGS and corresponding traits were examined in adults >
 50 years from the Health and Retirement Study (