This study aimed to analyse the chemical profiles of Hylotelephium species, hybrids, and cultivars in terms of headspace (HS) volatiles (by GC-MS/FID) and elemental composition (macro-/microelements) of roots and leaves (by ICP-OES). Contrary to the root HS fraction, the HS fraction of the leaf did not contain any volatiles. Generally, oxygenated monoterpenes are a dominant class of root HS volatiles, with monoterpenic alcohol myrtenol as a major compound followed by 1-octen-3-ol. Regarding the content of macroelements, the analyzed samples mostly contained the highest content of Ca or K and the smallest content of Na. Among microelements, Fe, Mn, and Zn were the most abundant in the root. Interestingly, the highest content of most microelements was detected in the studied species. Regarding the translocation factors (TF) for toxic elements, hybrids and cultivars proved better for accumulating heavy metals than species. Overall, both chemical profiles were statistically processed using multivariate analysis (AHC and PCA) to observe the tendency of grouping based on the chemical composition. According to the HS volatile pattern, a hybrid H. 'Matrona' and studied species were most separated, while macro- and microelements made the species root stand out most. H. 'Matrona' showed the greatest potential for the translocation.