LCK-co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity.

• Tác giả: Priyanka Chaurasia, Kim L Good-Jacobson, Zijian Huang, Claerwen M Jones, Nicole L La Gruta, Dene R Littler, Angela Nguyen, Trang T Nguyen, Hugh H Reid, Jeanette Rientjes, Jamie Rossjohn, Roland Ruscher, Stefan A Schattgen, Daniel Thiele, Paul G Thomas, Mai T Tran, Hui Xu, Pirooz Zareie, Justin B Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 599.314 *Myrmecophagidae
• Thông tin xuất bản: United States : Science immunology , 2025
• Bộ sưu tập: NCBI
• ID: 473461

Tóm tắt

The interaction between the CD4/CD8 co-receptors and LCK (an Src family tyrosine kinase) is thought to augment T cell activation upon recognition of peptide-loaded major histocompatibility complexes (pMHCs). How this interaction influences antigen-specific T cell development is unclear however, as is its impact on naïve and immune antigen-specific T cell repertoires. In mice expressing mutated endogenous LCK unable to bind co-receptors (LCK