UNLABELLED: Changes in glucose and insulin are potentially involved in the appetite-regulatory effects of exercise considering their role post-prandially. PURPOSE: To examine if glucose and insulin play a role in post-exercise appetite regulation. METHODS: 12 participants (M=8
26±5 y) completed 3 experimental sessions in a systematically rotated randomized crossover design: 1) no-exercise control (CTRL)
2) moderate-intensity continuous training (MICT
30-min, 70% maximal oxygen consumption (V̇O2max))
and 3) sprint interval training (SIT
4 x 30-s "all-out" sprints, interspersed with 4-min rest). Plasma glucose, insulin, acylated ghrelin, active peptide tyrosine tyrosine (PYY), active glucagon-like peptide-1 (GLP-1), and overall appetite perceptions were measured pre-exercise, 0-, 30-, 60-, and 120-min post-exercise. Energy intake was recorded the day before, of, and after experimental sessions. RESULTS: Glucose was elevated 0-min post-exercise (p<
0.097, d>
0.52) compared to CTRL with no differences between exercise bouts. Acylated ghrelin was suppressed by MICT (60-, 120-min) and SIT (0-, 30-, 60-, 120-min
p<
0.080, d>
0.56) compared to CTRL, while also suppressed in SIT compared to MICT at 30-, 60-, 120-min (p<
0.026, d>
0.74). GLP-1 was elevated following MICT (0-, 30-, 60-min) and SIT (60-min
p<
0.094, d>
0.53) compared to CTRL and following MICT compared to SIT (0-min
p=0.005, d=1.03). Overall appetite was suppressed by SIT post-exercise (p<
0.058, d>
0.61) compared to CTRL and MICT, and by MICT 0-min post-exercise compared to CTRL (p=0.036, d=0.71). There were no exercise effects on insulin, PYY, or free-living energy intake (p>
0.217, ηp2<
0.130). CONCLUSION: Glucose and insulin do not appear to play a role in exercise-induced appetite suppression.