Carnosine-enriched functional food enhances micro- and macrovascular endothelium-independent vasodilation in competitive athletes - a randomized study.

• Tác giả: Alina Boris, Ines Drenjancevic, Olivera Galović, Ivana Jukić, Nikolina Kolobarić, Manuela Košević, Gordana Kralik, Zlata Kralik, Zrinka Mihaljević, Leon Perić, Ana Stupin, Petar Šušnjara
• Ngôn ngữ: eng
• Ký hiệu phân loại: 333.3323 Private ownership of land
• Thông tin xuất bản: Canada : Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme , 2025
• Bộ sưu tập: NCBI
• ID: 473888

Tóm tắt

This randomized interventional study aimed to investigate the effect of carnosine-enriched chicken meat consumption on systemic endothelium-dependent and -independent micro- and macrovascular reactivity in thirty-five healthy competitive male athletes. Both forearm skin micro- and macrovascular endothelium-independent vasodilation were increased, and diastolic and mean arterial blood pressure (BP) were decreased in Carnosine group (n=19) following the 3-week dietary protocol. Microvascular endothelium-dependent response (PORH) was increased in the Carnosine group and significantly associated with decreased mean arterial BP level. Following dietary protocol, Controls (n =16) had substantially higher urate (but still normal) levels than the Carnosine group. Carnosine supplementation in the form of functional food enhances endothelium-dependent and vascular smooth muscle-dependent vasodilation in peripheral micro- and microcirculation. Carnosine's effect on vascular endothelium could be attributed to its blood pressure-lowering effect. Results suggest that carnosine has the potential to resist hyperuricemia in healthy individuals. (NCT05723939).