Thành phần hóa học của địa y Roccella sinensis thu hái ở tỉnh Bình Thuận=Chemical constituents of the lichen Roccella sinensis growing in Binh Thuan province

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Tác giả: Xuân Hào Bùi, Thúc Huy Dương

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Phát triển Khoa học & Công nghệ: Chuyên san Khoa học Tự nhiên, 2018

Mô tả vật lý:

Bộ sưu tập: Báo, Tạp chí

ID: 473911

Thêm vào giỏ

Loài địa Roccella sinensis chưa được nghiên cứu hóa học. Nghiên cứu này mô tả sự cô lập và xác định cấu trúc của các hợp chất cô lập từ địa y Rocccella sinensis thu hái ở tỉnh Bình Thuận. Khảo sát hoá học trên loài địa y này đã sử dụng các phương pháp sắc ký cột silica gel pha thường và sắc ký lớ mỏng. Sáu hợp chất đã được phân lập được. Cấu trúc của các hợp chất được xác định bằng các phương pháp phổ nghiệm cũng như so sánh với các dữ liệu có trong tài liệu tham khảo. Chúng là (+)-Dmontagnetol (1), (+)-D-erythrin (2), lecanorin (3), 1- acetylerythritol (4), (E)-nostodione A (5) và 2,4- dihydroxyphthalide (6). Đây là lần đầu tiên các hợp chất 3 6 được biết hiện diện trong chi Roccella. Khảo sát thử nghiệm hoạt tính gây độc tế bào trên bốn dòng tế bào ung thư HeLa, HepG2, NCI-H460 and MCF–7 của ba hợp chất 1, 2 và 6 cho thấy cả ba đều không hoạt tính.The lichen Roccella sinensis has not been studied chemically. This research described the isolation and elucidation of compounds isolated from the lichen Roccella sinensis collected in Binh Thuan. Phytochemistry investigation of this lichen was carried out by using normal phase silica gel column chromatography and thin-layer chromatography. Six compounds was isolated. Their structures were established by extensively spectroscopic analysis as well as comparison with NMR data in the literatures. They are (+)-D-montagnetol (1), (+)-D-erythrin (2), lecanorin (3), 1-acetylerythritol (4), (E)-nostodione A (5), and 2,4-dihydroxyphthalide (6). This is the first time compounds 3 6 were found in the Roccella genus. Compounds 1, 2, and 6 were evaluated for their cytotoxic activities against HepG2 (liver hepatocellular carcinoma), NCI-H460 (human lung cancer), MCF-7 (human breast cancer), and HeLa (human epithelial cancer) and all of them showed no activity.

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