We demonstrate the existence of topological phase transitions in interacting, symmetry-protected quantum matter at finite temperatures. Using a combined numerical and analytical approach, we study a one-dimensional Su-Schrieffer-Heeger model with added Hubbard interactions, where no thermodynamic phase transition occurs at finite temperatures. The transition is signalled by a quantized, nonlocal bulk topological order parameter. It is driven by defects, which are enabled by the combination of interaction and thermal activation, with no counterpart in the noninteracting limit. The defects localize topological zero modes, which, when sufficiently abundant, cause the order parameter to vanish. This phenomenon, interpreted via bulk-boundary correspondence, reflects the loss of a topological edge mode at a well-defined critical temperature in the thermodynamic limit. Unlike zero-temperature topological transitions, these finite-temperature transitions lack thermodynamic signatures but remain observable in controlled quantum systems, such as ultracold fermionic atoms in optical lattices.