Modeling forebrain regional development and connectivity by human brain organoids.

• Tác giả: Mu Seog Choe, Cynthia Lo, In-Hyun Park
• Ngôn ngữ: eng
• Ký hiệu phân loại: 005.746 Data compression
• Thông tin xuất bản: England : Current opinion in genetics & development , 2025
• Bộ sưu tập: NCBI
• ID: 474834
• Chủ đề: 1. Modeling; 2. Forebrain; 3. Regional

Tóm tắt

The forebrain is one of the most important brain structures for modern human existence, which houses the uniquely sophisticated social and cognitive functions that distinguish our species. Therefore, modeling the forebrain development by using human cells is especially critical for our understanding of the intricacies of human development and devising treatments for related diseases. Recent advancements in brain organoid fields have offered unprecedented tools to investigate forebrain development from studies on specific regions to exploring tract formation and connectivity between different regions of the forebrain. In this review, we discuss the developmental biology of the forebrain and diverse methods for modeling its development by using organoids.