Manganese dioxide coupled metal-organic framework as mitophagy regulator alleviates periodontitis through SIRT1-FOXO3-BNIP3 signaling axis.

• Tác giả: Bing Fang, Kai Huang, Yu Jin, Ruomei Li, Tiancheng Li, Yixin Li, Lunguo Xia, Shengbing Yang, Cheng Zhu, Zhiyu Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 496.3378 Niger-Congo languages
• Thông tin xuất bản: Netherlands : Biomaterials , 2025
• Bộ sưu tập: NCBI
• ID: 476038

Tóm tắt

Periodontitis is a prevalent chronic inflammatory disease characterized by alveolar bone resorption. Its progression is closely linked to oxidative stress where reactive oxygen species (ROS) generated by mitochondria exacerbate inflammation in positive feedback loops. Strategies for mitochondrial regulation hold potential for therapeutic advances. Metal-organic frameworks (MOFs) have shown promise as nanozymes for ROS scavenging. However, inability to directly regulate cellular processes to prevent further ROS production from damaged mitochondria during persistent inflammation makes MOFs insufficient in treating periodontitis. This study synthesizes MnO