Đặc điểm nồng độ vitamin D huyết thanh trên bệnh nhân mắc bệnh lý hô hấp tại Bệnh viện Đại học Y Hà Nội=Characteristics of serum vitamin d concentrations in patients with some respiratory diseases at Hanoi Medical University Hospital

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Tác giả: Văn Thái Lưu, Đức Tuấn Nguyễn, Thị Ngọc Lan Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Y học cộng đồng, 2023

Mô tả vật lý: tr.100-107

Bộ sưu tập: Metadata

ID: 477510

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Khảo sát đặc điểm nồng độ vitamin D huyết thanh trên nhóm bệnh nhân viêm phổi do mắc virus SARS-CoV-2 và một số bệnh lý hô hấp khác tại Bệnh viện Đại học Y Hà Nội. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 196 đối tượng nghiên cứu (ĐTNC) bao gồm 37 ĐTNC viêm phổi do mắc virus SARS-CoV-2, 35 ĐTNC mắc viêm phế quản, viêm phổi (VPQ/VP) do các tác nhân khác, 65 ĐTNC mắc hen, 15 ĐTNC mắc COPD. Kết quả: Tỷ lệ ĐTNC có tình trạng thiếu vitamin D nặng (dưới 20 ng/mL) của các nhóm trên lần lượt là 81,08%, 28,10%, 38,40%, 33,30%. Nồng độ vitamin D ở nhóm bệnh nhân viêm phổi do mắc virus SARS-CoV-2 thấp hơn so với các nhóm còn lại, sự khác biệt là có ý nghĩa thống kê p<
0,01. Tỷ lệ ĐTNC có tình trạng thiếu vitamin D rất nặng (dưới 10 ng/mL) ở nhóm bệnh nhân viêm phổi do mắc virus SARS-CoV-2 lên tới 37,80%. Bên cạnh đó, nhóm bệnh nhân viêm phổi do mắc virus SARS-CoV-2 có tiền sử bệnh lý đái tháo đường (ĐTĐ) có nồng độ vitamin D trung bình thấp hơn so với nhóm không mắc ĐTĐ (9,24 ± 3,47 ng/mL và 14,63 ± 7,45 ng/mL, p=0,004), tỷ lệ ĐTNC có nồng độ vitamin D dưới 10 ng/mL của 2 nhóm trên lần lượt là 58,30% và 28,00%, sự khác biệt là có ý nghĩa thống kê p<
0,05. Kết luận: Trong nhóm các bệnh nhân mắc bệnh lý hô hấp tại bệnh viện Đại học Y Hà Nội có tỷ lệ thiếu hụt vitamin D cao, trong đó nhóm bệnh nhân viêm phổi do mắc virus SARS-CoV-2 có tỷ lệ thiếu hụt vitamin D cao nhất.This study aims to survey of serum vitamin D concentration in a group of patients with SARS-CoV-2 infection and some other respiratory diseases at the Hospital of Hanoi Medical University. Subject and method: A cross-sectional descriptive study was conducted on 196 study subjects, including 37 pneumonia patients with SARS-CoV-2 infection, 35 study subjects with bronchitis and pneumonia, 65 study subjects with asthma, 15 study subjects with COPD. Results: The proportion of study subjects with severe vitamin D deficiency (below 20 ng/mL) in these groups were 81,08%, 28,10%, 38,40%, 33,30%. The vitamin D concentration in the pneumonia patients with SARS-CoV-2 infection group was lower compared to the other groups, the difference is statistically significant p<
0,01. The proportion of study subjects with very severe vitamin D deficiency (below 10 ng/mL) in the COVID-19 group was as high as 37,80%. Additionally, the pneumonia patients with SARS-CoV-2 infection group with a history of diabetes had a lower average vitamin D concentration compared to the group without underlying diabetes (9,24 ± 3,47 ng/mL and 14,63 ± 7,45 ng/mL, p=0,004), the proportion of study subjects with a vitamin D concentration below 10 ng/mL in these two groups were 58,30% and 28,00% respectively, the difference is statistically significant p<
0,05. Conclusion: In the group of patients with respiratory diseases at the Hospital of Hanoi Medical University, there was a high prevalence of vitamin D deficiency, in which the group of pneumonia patients with SARS-CoV-2 infection had the highest rate of vitamin D deficiency.

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