Một số đặc điểm của nhóm bệnh nhân xơ gan, ung thư biểu mô tế bào gan có tiền sử viêm gan B tại Bệnh viện Đại học Y Hà Nội=Some characteristics of cirrhosis patients and hepatocellular carcinoma patients with history of hepatitis B virus infection at Hanoi Medical University Hospital

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Tác giả: Đức Tuấn Nguyễn, Thị Ngọc Lan Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Y học cộng đồng, 2023

Mô tả vật lý: tr.234-240

Bộ sưu tập: Metadata

ID: 477544

Thêm vào giỏ

Cirrhosis and hepatocellular carcinoma due to chronic hepatitis B virus (HGB) infection are common diseases in our country today. Currently, the number of patients coming for examination and discovering current or past hepatitis B virus infection is increasing. Subject and method: Cross-sectional descriptive study was used to investigate the characteristics of 111 cirrhosis patients and 107 HCC patients infected with HBV at Hanoi Medical University. Results: In the cirrhotic group, there was 27.03% patients were found to have HBV at the time of admission and 72.97% had been previously diagnosed with HBV, among these, 45.68% was diagnosis over 10 years. Notably, the rate of patients diagnosed with cirrhosis at Child Pugh A level in the group of patients with previously detected HBV was 39.05%, this rate in the group of patients detected at the time of admission is 20.00%, the difference between the 2 groups is statistically significant. In the HCC group, there was 49.53% patients were found to have HBV at the time of admission and 50.47% had been previously diagnosed with HBV. Conclusion: There is a relationship between the stage of cirrhosis and the paraclinical indices AST, GGT, PT, INR, ALB, BIL, AFP, time to detect HBV infection, and there is also a relationship. between the stage of BMT and some paraclinical indicators such as AST, GGT, AFP.Nghiên cứu nhằm khảo sát các đặc điểm lâm sàng và xét nghiệm trên các bệnh nhân xơ gan và ung thư biểu mô tế bào gan trên nền viêm gan B là cần thiết để cung cấp thêm thông tin cho bác sỹ lâm sàng trong quá trình chẩn đoán và điều trị. Đối tượng và phương pháp nghiên cứu: Khảo sát đặc điểm của 111 bệnh nhân xơ gan và 107 bệnh nhân ung thư biểu mô tế bào gan (UTBMTBG) có tiền sử nhiễm virus viêm gan B tại bệnh viện Đại Học Y Hà Nội. Kết quả: Trong nhóm xơ gan, có 27,03% được phát hiện mắc viêm gan B (VGB) tại thời điểm vào viện và 72,97% đã từng phát hiện mắc viêm gan B trước đây, tỷ lệ bệnh nhân phát hiện viêm gan B trên 10 năm là 45,68%. Đáng chú ý, tỷ lệ bệnh nhân được chẩn đoán xơ gan ở mức độ Child Pugh A ở nhóm bệnh nhân đã được phát hiện VGB trước đây là 39,05%, tỷ lệ này ở nhóm bệnh nhân phát hiện tại thời điểm vào viện lần lượt là 20,00%, sự khác biệt giữa 2 nhóm có ý nghĩa thống kê. Trong nhóm UTBMTBG, có 49,53% được phát hiện mắc viêm gan B tại thời điểm vào viện và 50,47% đã từng phát hiện mắc viêm gan B trước đây. Nồng độ albumin ở nhóm xơ gan Child Pugh B, C thấp hơn nhóm Child Pugh A có ý nghĩa thống kê, nhưng sự khác biệt giữa các nhóm UTBMTBG thì không có ý nghĩa thống kê. Chưa tìm thấy sự khác biệt về nồng độ glucose giữa các nhóm bệnh nhân xơ gan và UTBMTBG. Giá trị chỉ số AFP, AST, GGT, INR, Bilirubin toàn phần ở nhóm xơ gan Child Pugh A thấp hơn nhóm Child Pugh B, C, có ý nghĩa thống kê. Nhóm bệnh nhân UTBMTBG ở giai đoạn Barcelona A, B có giá trị chỉ số AFP, AST, INR thấp hơn và chỉ số PT cao hơn với nhóm được chẩn đoán ở giai đoạn Barcelona C, D, sự khác biệt là có ý nghĩa thống kê. Kết luận: Có mối liên quan giữa giai đoạn xơ gan với các chỉ số cận lâm sàng Albumin, Bilirubin toàn phần, AST, GGT, PT, INR, AFP, thời gian phát hiện nhiễm virus VGB, bên cạnh đó cũng thấy có mối liên quan giữa giai đoạn của UTBMTBG với một số chỉ số cận lâm sàng như AST, GGT, AFP.

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