Nghiên cứu hiệu quả chống viêm, diệt khuẩn của plasma lạnh trên bệnh nhân có vết thương phần mềm nhiễm khuẩn=Study on effectiveness of anti-inflammatory, anti-microbial of cold plasma in patients with infectious wound

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Đình Tùng Đỗ, Hoàng Tùng Đỗ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Y học cộng đồng, 2023

Mô tả vật lý: tr.61-68

Bộ sưu tập: Metadata

ID: 477686

Thêm vào giỏ

Nghiên cứu nhằm đánh giá tính an toàn, hiệu quả chống viêm, diệt khuẩn tại vết thương của tia plasma được tạo ra từ máy PlasmaMed do Việt Nam sản xuất. Phương pháp: Nghiên cứu thử nghiệm lâm sàng, có đối chứng
đối tượng gồm 31 bệnh nhân có vết thương nhiễm khuẩn, trong đó có 20 bệnh nhân có 2 vùng vết thương tương đồng (chia ra 01 vùng nghiên cứu được chiếu tia plasma, 01 vùng đối chứng thay băng thường quy), 11 bệnh nhân chỉ có 1 vùng vết thương (vùng nghiên cứu được chiếu tia plasma). Các chỉ số đánh giá hiệu quả gồm: CRP, PCT, nồng độ vi khuẩn tại vết thương. Kết quả: Nghiên cứu cho thấy các chỉ số CRP, PCT ở bệnh nhân có vết thương giảm rõ rệt ngay sau khi chiếu plasma lạnh ở ngày thứ 1 và ngày thứ 5. Qua lần chiếu thứ nhất, nồng độ vi khuẩn tồn tại trên bề mặt nền vết thương đã giảm rất rõ rệt so với trước khi chiếu. Tại thời điểm ngày thứ 5 đa số bệnh nhân vết thương đã sạch khuẩn hoàn toàn. Đánh giá bằng hình ảnh cho thấy, vết thương đã chuyển biến tích cực: nhanh se, giảm tiết dịch, bờ mép vết thương đã liền, các mô phát triển khiến tổng thể bề mặt vết thương đồng màu. Kết luận: Plamsma lạnh có hiệu quả chống viêm và diệt khuẩn, phòng nhiễm khuẩn ở vết thương phần mềm ngay từ lần chiếu đầu tiên, cũng như sau 5 ngày.This study aims to assess the safety and effectiveness of using anti-inflammatory and bactericidal plasma generated from the PlasmaMed machine manufactured in Vietnam for treating infected wounds. Methods: This study was a controlled clinical trial involving 31 patients with infected wounds. Of the 31 patients, 20 had two similar wound areas, with one area treated with plasma irradiation while the other received routine dressing changes and served as the control group. The remaining 11 patients had only one wound area treated with plasma irradiation. The efficacy of the treatment was measured using various indicators, including C-reactive protein (CRP), procalcitonin (PCT), and bacterial concentration at the wound site. Results: The study showed a significant decrease in CRP and PCT levels immediately after the first and fifth day of cold plasma irradiation. Additionally, the concentration of bacteria on the wound surface was significantly reduced after the first plasma irradiation. By day 5, most of the patients’ wounds were completely clean, with positive changes observed, such as fast atrophy, reduced exudation, healing of wound edges, and tissue growth, resulting in a uniform coloration of the overall wound surface. Conclusion: Based on the study results, it can be concluded that cold plasma generated from the PlasmaMed machine has anti-inflammatory and bactericidal effects that can prevent infection in soft wounds immediately after the first exposure and up to five days after treatment.

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