Xác định độ nhạy cảm của một số thuốc điều trị với candida spp ở da, niêm mạc trên người bệnh điều trị tại Bệnh viện Phong Da liễu Trung ương Quy Hòa=Determination of the antifungal drug susceptibility of candida spp. isolated from skin and mucous membranes of patients treated at Quy Hoa National leprosy dermatology Hospital

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Đình Cảnh Hoàng, Quang Phục Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Y học cộng đồng, 2023

Mô tả vật lý: tr.141-147

Bộ sưu tập: Metadata

ID: 477709

Thêm vào giỏ

Candida spp, which causes skin and mucous membrane infection, is resistant to many antifungal drugs. This study was conducted to determine the sensitivity of Candida spp in patients treated at Quy Hoa National Leprosy Dermatology Hospital to find the most effective antifungal drugs. Study subjects and methods: The study was conducted in the laboratory with a descriptive research design. Results:C. albicans was sensitive to Amphotericin B, Econazole and Nystatin at high rates of 73.33%, 73.33% and 60.00%, respectively. C. tropicalis was susceptible to Amphotericin B at the rate of 75.00%, and resistant to 5-fluorocytosine, Ketoconazole and Miconazole at the resistance rate of 75.0%, 50.0%. C. glabrata was sensitive to many Miconazole-based antifungal drugs at 100%, to Amphotericin B at 75%, and to Fluconazole and Nystatin, but resistant to Ketoconazole, 5-fluorocytosine and Itraconazole at 50%. C. parapsilosis was susceptible to many antifungal drugs such as Clotrimazole, Itraconazole, Fluconazole, Nystatin and Amphotericin B at the rates of 100%. C. parapsilosis was resistant to 5-fluorocytosine and Miconazole at 50.0%. Conclusions: Most of the Candida spp, such as C. albicans, C. tropicalis, C. glabrata, C. glabratawere susceptible to Amphotericin B with susceptibility rates ranging from 75.0% to 100.0%.Đề tài xác định độ nhạy cảm của một số thuốc điều trị Candida spp ở da, niêm mạc trên người bệnh điều trị tại Bệnh viện Phong Da liễu Trung ương Quy Hòa nhằm tìm ra các loại thuốc có hiệu quả điều trị cao nhất. Đối tượng và phương pháp: Đề tài được thiết kế bằng phương pháp nghiên cứu mô tả thực nghiệm tại labo với bệnh nhân đến khám và điều trị bệnh da liễu tại Bệnh viện Phong Da liễu Trung ương Quy Hòa Kết quả: C. albicans nhạy cảm với Amphotericin B, Econazole và Nystatin với tỷ lệ cao 73,33%, 73,33% và 60,00%
C. tropicalis nhạy cảm với Amphotericin B với tỷ lệ là 75,00%, đã kháng với 5-fluorocytosine và Ketoconazol và Miconazole với tỷ lệ kháng là 75,0%, 50,0%
C. glabrata nhạy cảm với nhiều thuốc kháng nấm Miconazole là 100%, Amphotericin B là 75%, Fluconazole và Nystatin, nhưng đã kháng 50% với Ketoconazol và 5-fluorocytosine, Itraconazol
C. parapsilosis nhạy với nhiều thuốc kháng nấm như Clotrimazole, Itraconazol, Fluconazole, Nystatin và Amphotericin B chiếm 100%. C. parapsilosis kháng với 5-fluorocytosine và Miconazole chiếm tỷ lệ 50,0%. Kết luận: Độ nhạy cảm của Amphotericin B cao nhất trong các thuốc kháng nấm được thử nghiệm, tỷ lệ nhạy từ 75,0% đến 100,0% với hầu hết các chủng nấm C. albicans, C. tropicalis, C. glabrata, C. glabrata.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR