Xác định độ nhạy cảm với kháng sinh điều trị viêm phổi do phế cầu khuẩn ở trẻ em điều trị tại Bệnh viện Nhi Trung ương 2020=The susceptibility of streptococcus pneumoniae to antibiotics among children treated at the National Children’s Hospital, 2020

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Tác giả: Đình Cảnh Hoàng, Quang Thiều Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Y học cộng đồng, 2023

Mô tả vật lý: tr.175-183

Bộ sưu tập: Metadata

ID: 477718

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Đề tài xác định độ nhạy cảm với kháng sinh điều trị viêm phổi do phế cầu khuẩn ở trẻ em <
5 tuổi tại Bệnh viện Nhi Trung ương nhằm xác định kháng sinh có hiệu quả điề trị tốt nhất. Phương pháp nghiên cứu: Đề tài được thiết kế bằng phương pháp nghiên cứu mô tả thực nghiệm tại labo Kết quả: Phế cầu khuẩn có tỷ lệ kháng cao >
95% với các kháng sinh nhóm macrolid, kháng 90% với cotrimoxazol, kháng 95,3% với clindamycin. Phế cầu khuẩn đa kháng kháng sinh chiếm 64%. Tỷ lệ phế cầu khuẩn nhạy cảm 43,9% với penicillin G (MIC90=4 µg/ml), nhạy cảm 57,4% với cefotaxim (MIC90= 4 µg/ml), nhạy cảm 61,1% với ceftriaxon (MIC90= 4 µg/ml), nhạy cảm 95% với amoxicillin (MIC90 = 2 µg/ml), nhạy cảm 100% với rifampicin, linezolid và vancomycin. Kết luận: Phế cầu khuẩn đã kháng với nhiều họ kháng sinh penicillin, cephalosporin, sulfamid, macrolid. Còn nhạy cảm với họ rifampin, glycopeptid, oxazolidinon, quinolon. Vì vậy, khi điều trị viêm phổi do phế cầu cần làm kháng sinh đồ lựa chọn kháng sinh nhạy cảm nhất.Streptococcus pneumoniae causes severe diseases with a high mortality rate. The study aims to determine the susceptibility of Streptococcus pneumoniae to antibiotics among children aged <
5 years old at the National Children’s Hospital to find the most effective treatment. Study method: The study was conducted in the laboratory with a descriptive research design. Results: Streptococcus was resistant to macrolides (>
95%), cotrimoxazole (90%), and clindamycin (95.3%). Multiple antibiotic resistance Streptococcus accounted for 64%. In addition, 100% of Streptococcus were sensitive to rifampicin, linezolid and vancomycin, followed by amoxicillin (MIC90 = 2 μg/ml) at 95%, ceftriaxone (MIC90 = 4 μg/ml) at 61.1%, cefotaxime (MIC90 = 4 μg/ml) at 57.4%, and penicillin G (MIC90=4 μg/ml) at 43.9%. Conclusion: Streptococcus was resistant to penicillins, cephalosporins, sulphonamides, and macrolides. It was still sensitive to rifampin, glycopeptides, oxazolidinones, and quinolones. Therefore, the treatment of Streptococcus pneumoniae should be based on its antibiotic resistance patterns to find the most sensitive antibiotic.

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