So sánh hiệu quả của palonosetron với dexamethason trong điều trị dự phòng nôn và buồn nôn sau gây tê tủy sống mổ lấy thai=Comparing the effectiveness of palonosetron with dexamethason in preventing nausea and vomiting under spinal anesthesia for cesarean section

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Tác giả: Thị Hồng Xuyến Hoàng, Hoàng Hiệp Nguyễn, Huy Chiến Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.79-85

Bộ sưu tập: Metadata

ID: 477963

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So sánh hiệu quả của palonosetron với dexamethason trong điều trị dự phòng nôn và buồn nôn sau gây tê tủy sống mổ lấy thai. Đối tượng và phương pháp: sử dụng thiết kế nghiên cứu can nghiệm lâm sàng có đối chứng, sản phụ >
18 tuổi có chỉ định gây tê tủy sống để mổ lấy thai chủ động tại Bệnh viện Đại học Y Hà Nội. Nhóm P: 35 BN sử dụng 0,075mg Palonosetron tiêm tĩnh mạch trước khi GTTS 5 – 10 phút. Nhóm D: 35 BN sử dụng 8mg Dexamethason tiêm tĩnh mạch trước khi GTTS 5 – 10 phút. Kết quả: Mức độ nôn - buồn nôn trong và sau mổ nhóm D nặng hơn nhóm P. Trong mổ nhóm P có 8,6% BN NBN độ 1, và 5,7% BN NBN độ 2, Nhóm D có 8,6% BN NBN độ 1 và 14,3% BN nôn - buồn nôn độ 2. Sau mổ nhóm P có 8,6% BN NBN độ 1, 5,7% BN NBN độ 2, 2,9% BN NBN độ 3, nhóm D có 17,1% BN nôn, buồn nôn độ 1 và 5,7% BN NBN độ 2, 5,7% BN NBN độ 3 và 2,9% BN NBN độ 4. Các tác dụng không mong muốn ở nhóm D cao hơn nhóm P như run (20% ở nhóm D và 14,3% ở nhóm P), đau đầu, dị ứng (5,7% ở nhóm D và 2,9% ở nhóm P). Kết luận: Để đạt hiệu quả cao trong dự phòng nôn - buồn nôn trong và sau mổ lấy thai cần dự phòng bằng palonosetron nhằm cải thiện chất lượng chăm sóc y tế và rút ngắn thời gian hồi phục.To compare the effectiveness of palonosetron with dexamethason in preventing nausea and vomiting under spinal anesthesia for cesarean section. Subjects and methods: Using a controlled clinical trial design, pregnant women >
18 years old were prescribed spinal anesthesia for elective cesarean section at Hanoi Medical University Hospital. Group P: 35 patients used 0.075 mg Palonosetron injected intravenously 5 - 10 minutes before spinal anesthesia. Group D: 35 patients used 8 mg of Dexamethasone injected intravenously 5 - 10 minutes before spinal anesthesia. Results: The level of nausea and vomiting during and after surgery in group D was more severe than in group P. During surgery, group P had 8.6% of patients with level 1 of nausea and vomiting, and 5.7% of patients with level 2 of nausea and vomiting, Group D showed 8.6% % of patients with level 1 nausea and vomiting, and 14.3% of patients with level 2 nausea and vomiting. After surgery, group P indicated 8.6% of patients with level 1 nausea and vomiting, 5.7% of patients with level 2 nausea and vomiting, 2.9% of patients with level 3, Group D presented 17.1% of patients with level 1 nausea and vomiting, 5.7% of patients with level 2 nausea and vomiting, 5.7% of patients with level 3 nausea and vomiting, and 2.9% of patients with level 4 nausea and vomiting. Unwanted effects in group D were found higher than in group P such as tremor (20% in group D and 14.3% in group P), headache, allergies (5.7% in group D and 2.9% in group P). Conclusion: To achieve high effectiveness in nausea and vomiting prevention during and after cesarean section, prophylaxis with palonosetron is needed to improve the quality of medical care and shorten recovery time.

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