Nghiên cứu đặc điểm mô bệnh học và một số dưới típ tế bào T trong vi môi trường miễn dịch ung thư biểu mô tuyến dạ dày=Research on histopathological characteristics and some T-cell subtypes in the immune microenvironment of gastric adenocarcinoma

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Đức Tân Nguyễn, Đức Thắng Nguyễn, Thị Ngọc Mai Phạm, Thị Hồng Nhung Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.214-223

Bộ sưu tập: Metadata

ID: 478003

Thêm vào giỏ

Describe some histopathological features of gastric adenocarcinoma according to the World Health Organization (WHO) 2019 classification and compare them with CD4 and CD8 characteristics. Methods: Cross-sectional descriptive study, retrospective combined with prospective
Retrospective: 58 patients, prospective: 25 patients. Results: Tubular adenocarcinoma is the most common histopathological type of gastric adenocarcinoma, accounting for 74.7%
of which 51.9% had serosal invasion, and 63.9% had lymph node metastasis. The mean number of CD8+ T cells in the tumor tissue was 979 ± 458 cells, and CD4+ T cells were 1043 ± 561 cells. In the tumor stroma, the mean number of CD8+ T cells was 514 ± 306 cells, and CD4+ T cells were 512 ± 420 cells. In the tumor tissue, the density of CD4+ and CD8+ T cells was highest in the mucinous subtype (1637 cells/mm² and 1534 cells/mm²) and in T3 stage tumors (1306 cells/mm² and 1222 cells/mm²). The average density of CD4+ cells in tumors with and without lymph node metastasis was 1087 and 1011 cells/mm², respectively. The average density of CD8+ cells in tumors with and without lymph node metastasis was 942 and 1006 cells/mm², respectively. Conclusion: In gastric adenocarcinoma, the tubular subtype is the most common. The mucinous subtype and T3 stage tumors exhibit the highest levels of CD4+ and CD8+ T cell expression in tumor tissue. There is a correlation between CD8+ T cell density and lymph node metastasis.Mô tả một số đặc điểm mô bệnh học của ung thư biểu mô tuyến dạ dày theo phân loại của tổ chức y tế thế giới 2019 và đối chiếu với đặc điểm CD4 và CD8 ở nhóm đối tượng nghiên cứu. Phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang, hồi cứu kết hợp tiến cứu
hồi cứu: 58 bệnh nhân, tiến cứu: 25 bệnh nhân. Kết quả: UTBM tuyến ống là típ mô bệnh học thường gặp nhất trong ung thư biểu mô dạ dày chiếm tỷ lệ 74,7%
trong đó có 51,9% có xâm lấn thanh mạc
63,9% có di căn hạch. Giá trị trung bình trong mô u của T CD8 là 979 ± 458 tế bào, của T CD4 là 1043 ±561 tế bào. Giá trị trung bình trong mô đệm u của T CD8 là 514 ± 306 tế bào, của T CD4 là 512 ± 420 tế bào. Trong mô u mật độ tế bào T CD4 và TCD8 bộc lộ cao ở típ chế nhầy (1637 tế bào/mm² và 1534 tế bào/mm²) và giai đoạn u T3 ((1306 tế bào/mm² và 1222 tế bào/mm²). Mật độ trung bình tế bào bộc lộ CD4 trong u của các nhóm u có di căn hạch và không có di căn hạch lần lượt là 1087 và 1011 (tế bào/mm2), Mật độ trung bình tế bào bộc lộ CD8 trong u cuả các nhóm u có di căn hạch và không có di căn hạch lần lượt là 942 và 1006 (tế bào/mm2). Kết luận: Trong UTDD, típ tuyến ống là típ thường gặp nhất, típ tuyến nhày và giai đoạn u T3 có mức độ bộc lộ T CD4 và T CD8 trong mô u cao nhất. Có mối liên quan giữa mật độ T CD8 và di căn hạch.

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