Liệu pháp hướng đích ức chế trục tín hiệu IL-8/CXCR1/2 trong điều trị ung thư=Targeted therapy inhibiting IL-8/CXCR1/2 signaling pathway in cancer treatment

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Tác giả: Hương Ly Lê, Thanh Trang Nguyễn, Thị Thu Trang Nguyễn, Quế Hương Trần, Thị Thúy Nga Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.500-506

Bộ sưu tập: Metadata

ID: 478096

Thêm vào giỏ

IL-8 and its receptors, CXCR1 and CXCR2 have been extensively explored in cancer research. As a chemoattractant for N2-phenotype neutrophils and myeloid-derived suppressor cells, IL-8 and CXCR1/2 can modulate the tumor microenvironment to facilitate tumor evasion from immune cells. As an inducer of the transdifferentiation process epithelial-tomesenchymal transition, IL-8/CXR1/2 can promote invasion, metastasis, and contribute to resistance to immunotherapy or chemotherapy in tumor cells. Various preclinical and clinical studies targeting IL-8/CXCR1/2, are already being conducted to evaluate the effectiveness of this promising strategy in cancer treatment and overcoming resistance. Targeted therapies include small-molecule allosteric CXCR1/2 inhibitors, neutralizing antibodies against IL-8 or CXCR1/2, and IL-8-releasing inhibitors. The review highlights the dual roles that IL-8 and CXCR1/2 receptors play in both tumor progression and promoting tumor resistance. Subsequently, it also discusses the potential of targeted therapy aimed at inhibiting IL- 8/CXCR1/2 in treating cancer diseases and combating resistance mechanisms.Interleukin-8 (IL-8) và thụ thể của nó, CXCR1 và CXCR2, đã được khám phá rộng rãi trong các nghiên cứu ung thư. Là yếu tố huy động bạch cầu trung tính kiểu hình N2 và tế bào ức chế có nguồn gốc tủy, IL-8 và thụ thể CXCR1/2 có thể điều hòa môi trường vi mô khối u tạo điều kiện cho khối u trốn thoát các tế bào miễn dịch. Đồng thời, là tín hiệu gây cảm ứng quá trình chuyển đổi biệt hóa từ biểu mô sang trung mô, IL-8/CXCR1/2 có thể thúc đẩy sự xâm lấn và di căn cũng như liên quan đến khả năng kháng liệu pháp miễn dịch hoặc hóa trị của các tế bào khối u. Những nghiên cứu tiền lâm sàng hoặc lâm sàng nhắm mục tiêu IL-8/CXCR1/2 đã và đang được thực hiện để đánh giá hiệu quả của chiến lược đầy hứa hẹn này trong điều trị bệnh ung thư và hạn chế tình trạng kháng miễn dịch/hóa trị của khối u. Bao gồm các phân tử nhỏ ức chế thụ thể CXCR1/2 allosteric, kháng thể đơn dòng kháng IL-8 hoặc CXCR1/2 hoặc chất ức chế sự biểu hiện IL-8. Tổng quan này nêu bật vai trò kép của IL-8 và thụ thể CXCR1/2 trong quá trình tiến triển của tế bào khối u cũng như trong việc thúc đẩy khả năng kháng thuốc của các tế bào này. Sau đó thảo luận tiềm năng của liệu pháp hướng đích ức chế IL-8/CXCR1/2 trong điều trị bệnh lý ung thư và chống lại các cơ chế kháng thuốc.

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