Đặc điểm lâm sàng, mô bệnh học và thời gian sống thêm ở bệnh nhân ung thư vú dưới 40 tuổi điều trị tại bệnh viện Trung ương Thái Nguyên=Clinical, histopathological, and survival characteristics of breast cancer patients under 40 at Thai Nguyen National hospital

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Tác giả: Thị Kim Phượng Trần, Thị Hồng Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.82-89

Bộ sưu tập: Metadata

ID: 478118

Thêm vào giỏ

describe clinical and histopathological characteristics and to analyze survival outcome of breast cancer patients under 40 at Thai Nguyen National Hospital. Subjects and methods: A cross-sectional, retrospective descriptive study on patients with breast cancer patients under 40 diagnosed and treated at Thai Nguyen National Hospital from Jan 2016 to Jun 2023. Results: 71 patients were included. The average age was 35 ± 3.6. Stage II was the most common stage with 62.0%. Invasive ductal carcinoma and histological grade 2 were the most common, occurring in 85.9% and 83.6% of patients, respectively)
69% of patients had positive hormone receptor, triple-negative patients accounted for 31%, and the rate of Her- 2/neu (+) was 33.8%
5-year OS and DFS were 87.6% and 76.8% respectively. Conclusion: Breast cancer in young women had some favorable factors such as mostly diagnosed at an early stage, high prevalence of positive hormone receptor, but we also noticed unfavorable factors such as young age, HER2 (+), and triple-negative, that affected the overall prognosis. To determine the association of these characteristics with treatment outcomes in order to recommend the prognostic factors, more indepth research on clinical and histopathological characteristics as well as survival outcomes is needed.Mô tả một số đặc điểm lâm sàng và mô bệnh học ở bệnh nhân ung thư vú trẻ tuổi điều trị tại Bệnh viện Trung ương Thái Nguyên. Phân tích thời gian sống thêm ở nhóm bệnh nhân nghiên cứu trên. Đối tượng và phương pháp: Mô tả cắt ngang trên bệnh nhân ung thư vú dưới 40 tuổi được chẩn đoán và điều trị tại bệnh viện Trung ương Thái Nguyên từ tháng 01/2016 đến tháng 6/2023. Kết quả: Tổng số bệnh nhân trong nghiên cứu là 71. Độ tuổi trung bình là 35 ± 3,6. Giai đoạn bệnh hay gặp là giai đoạn II (62,0%). Ung thư biểu mô thể ống xâm nhập và độ mô học 2 là hay gặp nhất với tỷ lệ lần lượt là 85,9%
83,6%. 69,0% bệnh nhân có thụ thể nội tiết (TTNT) (+). Tỷ lệ Her-2/neu (+) là 33,8%
nhóm bệnh nhân thuộc nhóm bộ ba âm tính chiếm 31,0%. Tỷ lệ sống thêm toàn bộ và sống thêm không bệnh tại thời điểm 5 năm lần lượt là 87,6%, 76,8%. Kết luận: Ung thư vú ở phụ nữ trẻ có một số yếu tố thuận lợi như chẩn đoán ở giai đoạn sớm, TTNT (+), nhưng còn có các yếu tố không thuận lợi như tuổi trẻ, bộc lộ Her2 làm ảnh hưởng đến tiên lượng chung của bệnh. Để xác định mối quan hệ của các đặc điểm này với kết quả điều trị góp phần khuyến cáo về các yếu tố tiên lượng, cần có nhiều nghiên cứu sâu hơn nữa về đặc điểm lâm sàng, mô bệnh học cũng như kết quả sống thêm.

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