Đặc điểm lâm sàng, cận lâm sàng và kết quả sống thêm ở bệnh nhân ung thư vú cao tuổi điều trị tại bệnh viện Trung ương Thái Nguyên=The clinical, paraclinical characteristics and survival of elderly breast cancer patients at Thai Nguyen National hospital

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Tác giả: Việt Chinh Nguyễn, Thị Kim Phượng Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.90-98

Bộ sưu tập: Metadata

ID: 478119

Thêm vào giỏ

Mô tả một số đặc điểm lâm sàng, cận lâm sàng và phân tính thời gian sống thêm ở bệnh nhân ung thư vú cao tuổi điều trị tại Bệnh viện Trung ương Thái Nguyên Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang tiến hành trên bệnh nhân được chẩn đoán và điều trị tại Trung tâm Ung Bướu - Bệnh viện Trung ương Thái Nguyên từ tháng 01/2016 đến tháng 6/2024. Kết quả: 76 bệnh nhân đủ điều kiện tham gia nghiên cứu. Tuổi trung bình là 66,14 ± 3,8, trong đó nhóm tuổi 60-65 chiếm nhiều nhất là 34 bệnh nhân (44,7%). Bệnh ở giai đoạn II gặp nhiều nhất là 51 (67,1%) bệnh nhân, bệnh ở giai đoạn III gặp ở 17 (22,4%) bệnh nhân. Về đặc điểm mô bệnh học, 63 (82,9%) bệnh nhân có giải phẫu bệnh UTBM xâm nhập không phải loại đặc biệt, ER dương tính gặp ở 51 (67,1%) bệnh nhân, 24 (31,6%) bệnh nhân có bộc lộ qua mức Her2/neu. Thời gian sống thêm toàn bộ trung bình 39,1 ± 24,4 tháng. Thời gian sống thêm không bệnh trung bình là 36,9 ± 25,8 tháng. Tỷ lệ sống thêm toàn bộ tại thời điểm 5 năm liên quan có ý nghĩa thống kê với giai đoạn bệnh (p<
0,001), tình trạng di căn hạch (p=0,003) và độ mô học (p=0,018). Kết luận: Ung thư vú ở phụ nữ cao hay gặp ở giai đoạn II, có thụ thể nội tiết dương tính và Her-2/neu âm tính. Tỉ lệ sống thêm có liên quan đến giai đoạn bệnh, tình trạng di căn hạch và độ mô học.To describe clinical and paraclinical characteristics, and to analyze survival outcomes of elderly breast cancer patients at Thai Nguyen National Hospital Subjects and methods: The cross-sectional descriptive study was performed on elderly breast cancer patients treated at Thai Nguyen National Hospital from 01/2016 to 06/2024. Result: 76 eligible patients were enrolled. Their average age was 66.14 ± 3.8 years, in which the 60-65 age group had the highest number with 34 patients (44.7%). Stage II was the most common stage with 51 patients (67.1%) while stage III was diagnosed in 17 patients (22.4%). In terms of histopathological characteristics, 63 patients (82.9%) had invasive carcinoma of no-special type breast cancer
ERpositive was observed in 51 patients (67.1%)
24 patients (31.6%) had HER-2/neu gene amplification. The average overall survival (OS) time was 39.1 ± 24.4 months. The average disease-free survival (DFS) time was 36.9 ± 25.8 months. The 5-year OS rate was statistically significantly associated with disease stage (p<
0.001), lymph node metastasis (p=0.003), and histological grade (p=0.018). Conclusion: The most common clinical and paraclinical characteristics of elderly breast cancer patients include stage II, hormone receptor-positive, and Her-2/neu - negative. Survival rate was associated with disease stage, lymph node metastasis, and histological grade.

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