Kết quả điều trị ung thư đại trực tràng giai đoạn di căn xa bằng phác đồ FOLFIRI tại bệnh viện Trung ương Thái Nguyên=The efficacy of FOLFIRI regimen in treatment for patients with metastatic colorectal cancer at Thai Nguyen Central hospital

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Tác giả: Ánh Ngọc Trịnh, Trần Doanh Vi

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.186-193

Bộ sưu tập: Báo, Tạp chí

ID: 478138

Thêm vào giỏ

Mô tả một số đặc điểm lâm sàng, cận lâm sàng, đáp ứng điều trị và mối liên quan giữa đáp ứng điều trị với một số yếu tố trên bệnh nhân ung thư đại trực tràng giai đoạn di căn xa được điều trị bằng phác đồ FOLFIRI giai đoạn 2020-2024. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên bệnh nhân được chẩn đoán ung đại trực tràng giai đoạn di căn xa, được điều trị bằng phác đồ FOLFIRI tại Trung tâm Ung Bướu - Bệnh viện Trung ương Thái Nguyên từ tháng 03/2021 đến tháng 06/2024. Kết quả: 51 bệnh nhân được lựa chọn vào nghiên cứu. Tuổi trung bình của đối tượng nghiên cứu là 59,5. Bệnh nhân có PS 0 và PS 1 lần lượt là 24 (47,1%) và 26 (51,0%) bệnh nhân. Có 29 (56,9%) bệnh nhân có di căn 1 vị trí, di căn gan chiếm tỷ lệ cao nhất ở 39 (76,5%) bệnh nhân. Phần lớn bệnh nhân có mô bệnh học UTBM tuyến biệt hóa vừa, gặp ở 38 (74,5%) bệnh nhân. Tỷ lệ bệnh nhân đáp ứng một phần là 19/51 (37,3%)
bệnh giữ nguyên là 22/51 (43,1%)
tỷ lệ kiểm soát bệnh đạt 80,4%. Số lượng tạng di căn, thể mô bệnh học, chỉ số toàn trạng là một số yếu tố liên quan đến tỷ lệ đáp ứng. Kết luận: Phác đồ FOLFIRI là một lựa chọn hiệu quả trên bệnh nhân ung thư đại trực tràng giai đoạn di căn xa.to describe some clinical and paraclinical characteristics, treatment response, and the association between treatment response and some factors in patients with metastatic colorectal cancer treated with the FOLFIRI regimen in the period 2020-2024. Subjects and methods: A cross-sectional descriptive study on patients diagnosed with metastatic colorectal cancer, treated with the FOLFIRI regimen at the Oncology Center - Thai Nguyen Central Hospital from March 2021 to June 2024. Result: 51 patients were selected for the study. Their mean age was 59.5 years. Number of patients with PS 0 and PS 1 were 24 (47.1%) and 26 (51.0%), respectively. There were 29 (56.9%) patients with single-site metastasis
liver metastasis accounted for the highest proportion with 39 (76.5%) patients. The majority of patients had moderately differentiated adenocarcinoma histology, occurring in 38 (74.5%) patients. The rate of partial response patients was 19/51 (37.3%)
the disease was stable in 22/51 patients (43.1%)
the disease control rate was 80.4%. The number of metastatic organs, histopathology, and performance status were associated factors of the response rate. Conclusion: FOLFIRI regimen is an effective option for patients with metastatic colorectal cancer.

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