Một số đặc điểm lâm sàng, cận lâm sàng của bệnh nhân ung thư biểu mô gan nguyên phát giai đoạn trung gian tại bệnh viện Đa khoa tỉnh Thái Bình=Some clinical and subclinical characteristics of patients with intermediate-stage hepatocellular carcinoma at Thai Binh provincial general hospital

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Tác giả: Thị Oanh Đào

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.211-219

Bộ sưu tập: Metadata

ID: 478142

Thêm vào giỏ

Nhận xét một số đặc điểm lâm sàng, cận lâm sàng bệnh nhân ung thư biểu mô gan nguyên phát giai đoạn trung gian tại BVĐK tỉnh Thái Bình. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả hồi cứu trên các bệnh nhân được chẩn đoán ung thư biểu mô tế bào gan nguyên phát giai đoạn trung gian tại bệnh viện Đa khoa tỉnh Thái Bình từ tháng 01/2020 đến tháng 05/2023. Kết quả: Có 51 bệnh nhân tham gia nghiên cứu, tuổi trung bình là 64,6 ± 9,4
trong đó có 46 bệnh nhân nam, chiếm 90,2%. Có 22 (43,1%) bệnh nhân nhiễm HBV và 6 (11,8%) bệnh nhân nhiễm HCV. Triệu chứng mệt mỏi gặp ở 31 (60,8%) bệnh nhân, 12 (23,5%) bệnh nhân có triệu chứng gan to. Có 48 (94,1%) bệnh nhân chức năng gan Child-Pugh A, có 25 (49%) bệnh nhân có nồng độ AFP trước điều trị >
400ng/ml. Có 22 (43,1%) bệnh nhân có một khối u, 18 (35,3%) bệnh nhân có hai khối u và 11 (19,6%) bệnh nhân có từ ba khối u trở lên. Có 92 (96,1%) khối u có hình ảnh ngấm thuốc điển hình, kích thước u trung bình là 4,8 ± 2,1 cm. Khối u gan phải chiếm 79/92 (85,9%) tổng số khối u. Có 31 (60,8%) bệnh nhân được chẩn đoán bằng tiêu chuẩn chẩn đoán hình ảnh phối hợp AFP và 20 (39,2%) bệnh nhân cần sinh thiết chẩn đoán giải phẫu bệnh. Kết luận: Bệnh nhân ung thư gan tại bệnh viện đa khoa tỉnh Thái bình có một số đặc điểm: phần lớn bệnh nhân là nam giới, có nhiễm viêm gan B, có tăng AFP cao >
400ng/ml, chức năng gan Child Pugh A, có khối u gan ngấm thuốc điển hình trên chẩn đoán hình ảnh, khối u chủ yếu ở gan phải.To review some clinical and subclinical characteristics of patients with intermediate-stage hepatocellular carcinoma (HCC) at Thai Binh Provincial General Hospital. Research subjects and methods: Retrospective descriptive study on patients diagnosed with intermediate-stage HCC at Thai Binh Provincial General Hospital from January 2020 to May 2023. Results: Totally 51 patients were enrolled. The mean age was 64.6 ± 9.4 years
46 patients were male, accounting for 90.2%. There were 22 (43.1%) patients infected with HBV and 6 (11.8%) patients infected with HCV. Fatigue was present in 31 (60.8%) patients, while 12 (23.5%) had hepatomegaly. There were 48 (94.1%) patients with Child-Pugh A liver function, and 25 (49%) patients had pre-treatment AFP levels >
400ng/ml. There were 22 (43.1%) patients with one tumor, 18 (35.3%) with two tumors, and 11 (19.6%) patients with three or more tumors. Typical enhancement appeared in 92 (96.1%) tumors. The average tumor size was 4.8 ± 2.1 cm. Right lobe tumors accounted for 79/92 (85.9%) of all tumors. Thirty-one (60.8%) patients were diagnosed by combined imaging criteria with AFP, while biopsy for pathological diagnosis were required for 20 (39.2%) patients. Conclusion: HCC patients at Thai Binh Provincial General Hospital had following characteristics: most were male, infected with hepatitis B, had high AFP level (>
400ng/ml), Child-Pugh A liver function, typical contrastenhanced liver tumors on diagnostic imaging, tumors were mainly in the right liver lobe.

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