Hiệu quả của biafine trong dự phòng viêm da do xạ trị ở bệnh nhân ung thư đang điều trị tại bệnh viện Trung ương Huế=Effectiveness of biafine in preventing of radiation dermatitis in cancer patients at Hue central hospital

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Tác giả: Thị Liên Hương Bùi, Thị Thanh Xuân Hà, Khoa Anh Chil Nguyễn, Thị Cẩm Tuyền Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.229-235

Bộ sưu tập: Metadata

ID: 478148

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Mô tả tình trạng da ở bệnh nhân xạ trị có dùng và không dùng Biafine, từ đó đánh giá hiệu quả của Biafine trong việc dự phòng viêm da trong xạ trị. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên bệnh nhân ung thư được điều trị xạ trị vùng đầu, cổ, vú, ngực có hoặc không có dùng Biafine. Kết quả: 68 bệnh nhân được lựa chọn vào nghiên cứu.Trong đó 42 bệnh nhân có dùng Biafine chiếm 61,8%, 26 (38,2%) bệnh nhân không dùng Biafine. Có 48 (70,6%) bệnh nhân bị tổn thương da ở mức độ 1, không có trường hợp tổn thương da nào từ độ 2 trở lên sau 2 tuần xạ trị. Tỷ lệ đỏ da, ngứa/châm chích và nóng rát ở nhóm không dùng Biafine cao hơn so với nhóm có dùng Biafine. Triệu chứng đau ở nhóm không dùng Biafine là 10/26 (38,5%) bệnh nhân, cao hơn nhóm có dùng Biafine là 12/42 (28,6%) bệnh nhân. Nhóm bệnh nhân không dùng Biafine có tỷ lệ tổn thương da cao hơn ở 21/26 (80,8%) bệnh nhân so với nhóm bệnh nhân có dùng Biafine 27/42 (64,3%) bệnh nhân. Kết luận: Trong nghiên cứu của chúng tôi quan sát thấy sự cải thiện về các triệu chứng của viêm da ở nhóm bệnh nhân dùng Biafine. Cần tăng thêm cỡ mẫu nghiên cứu để tăng sự chính xác trong ước lượng thống kê.To describe the skin condition in patients undergoing radiation therapy with and without using of Biafine, and to evaluate the effectiveness of Biafine in preventing radiation dermatitis. Methods: A cross-sectional descriptive study was conducted in patients who underwent radiation therapy of head and neck, breast, and thoracic sites. Results: 68 patients were enrolled in this study. There were 42 patients received Biafine account for 61.8%, other 26 (38.2%) patients did not use Biafine. There were 48 (70.6%) patients experienced grade 1 dermatitis
no grade-2- orhigher dermatitis cases were observed after two weeks of radiotherapy. The proportion of patients having rash, itchy, burning skin was higher in the non-Biafine group. Pain symptom appeared in 10 patients of the non-Biafine group (38.5%), the rate was higher than that of the Biafine group (12 patients -28.6%). The non-Biafine group had a higher rate of dermatitis (80.8% - 21/26 patients), whereas this rate in the Biafine group is 64.3% (27/42). Conclusion: Our study observed the improvement of dermatitis symptoms in Biafine users during radiation therapy. It is necessary to increase the sample size to increase the accuracy of statistical estimation.

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