Khảo sát thực trạng kê đơn trên bệnh nhân ung thư điều trị hóa chất tại bệnh viện Ung Bướu Hà Nội=Evaluation of prescription patterns for cancer patients undergoing chemotherapy at Hanoi Oncology hospital

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Tác giả: Hoài Thu Đặng, Thị Ngọc Châu Điều, Ngọc Binh Lý, Minh Tuân Trần, Ngọc Phương Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.243-251

Bộ sưu tập: Metadata

ID: 478154

Thêm vào giỏ

Nghiên cứu được tiến hành nhằm khảo sát đặc điểm kê đơn và đánh giá các tương tác thuốc gặp phải trong đơn kê trên các bệnh nhân ung thư điều trị hóa chất tại bệnh viện Ung Bướu Hà Nội. Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang, mô tả hồi cứu dữ liệu thực hiện trên toàn bộ bệnh nhân ung thư điều trị hóa chất trong thời điểm từ 01/01/2022-31/12/2022 thỏa mãn các tiêu chuẩn lựa chọn và loại trừ đã được đưa vào nghiên cứu. Kết quả: 3911 bệnh nhân với 84619 lượt kê đơn đã được đưa vào phân tích. Độ tuổi trung bình của bệnh nhân trong nghiên cứu là 59,4. Bệnh lý ung thư điển hình là ung thư vú (21,3%), ung thư phổi (18,6%) và ung thư đại tràng (10,7%). Số thuốc trung bình/đơn là 7 thuốc/đơn, trong đó nhóm đơn hóa chất kết hợp thuốc điều trị ung thư khác trung bình là 14,3 thu ốc/đơn. Các nhóm thuốc hỗ trợ được dùng chủ yếu lần lượt là corticoid, PPI và kháng sinh với tỉ lệ lần lượt là 63,7%, 40,2% và 26%. Đã xác định được 5 cặp tương tác thuốc trên 37 lượt kê đơn và trên 17 bệnh nhân, đó là erlotinib - pantoprazol, fluconazol - ondansetron, domperidone maleate - fluconazol, fluorouracil - metronidazol và gefitinib - pantoprazol. Kết luận: Nghiên cứu cho thấy mặc dù tỉ lệ thuốc trung bình trên đơn thuốc khá cao trên bệnh nhân ung thư, tỉ lệ tương tác thuốc rất thấp, chỉ xuất hiện ở 37 trong số 84619 đơn kê.This study aimed to investigate the prescription characteristics and evaluate the drug-drug interactions encountered in prescriptions for cancer patients undergoing chemotherapy at Hanoi Oncology Hospital. Materials and methods: A retrospective cross-sectional descriptive study on cancer patients receiving chemotherapy from January 1, 2022, to December 31, 2022. Results: Totally 3911 eligible patients were enrolled with 84,619 prescriptions were analyzed. The average age of patients was 59.4 years. Common cancer types included breast cancer (21.3%), lung cancer (18.6%), and colorectal cancer (10.7%). The average number of drugs per prescription was 7, with prescriptions containing chemotherapy and other cancer treatments averaging 14.3 drugs per prescription. The most commonly used supportive drug groups were corticosteroids, proton pump inhibitors (PPIs), and antibiotics, with usage rates of 63.7%, 40.2%, and 26%, respectively. Five drug interaction pairs were identified in 37 prescriptions across 17 patients, including erlotinib-pantoprazole, fluconazoleondansetron, domperidone maleate - fluconazole, fluorouracil-metronidazole, and gefitinibpantoprazole. Conclusion: although the average number of drugs per prescription for cancer patients was relatively high, drug interactions rarely occurred (appeared in 37/84,619 prescriptions).

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